A single intranasal or intramuscular immunization with chimpanzee adenovirus vectored SARS-CoV-2 vaccine protects against pneumonia in hamsters.
T. Bricker, T. Darling, A. Hassan, H. Harastani, A. Soung, X. Jiang, Y.-N. Dai, H. Zhao, L. Adams, M. Holtzman, A. Bailey, J. B. Case, D. Fremont, R. S. Klein, M. Diamond, A. Boon
This study compares intranasal and intramuscular delivery of a chimpanzee adenovirus-vectored SARS-CoV-2 vaccine in hamsters, finding that intranasal immunization provides superior protection against infection and inflammation.
bioRxiv · Dec 2, 2020Microbiology