BioengineeringbioRxiv
Transitional alveolar epithelial cells and microenvironmental stiffness synergistically drive fibroblast activation in three-dimensional hydrogel lung models
T. Caracena, R. Blomberg, R. S. Hewawasam…·C. M. Magin
This paper develops a 3D hydrogel model of lung tissue to study fibroblast activation in IPF, showing that transitional epithelial cells and microenvironmental stiffness synergistically drive myofibroblast activation.
DOI 10.1039/d2bm00827k