T. Christian

This study elucidates the catalytic mechanism of Nep1 using molecular dynamics and quantum chemical calculations, revealing that water mediates proton transfer rather than a conserved serine residue.

This study shows that m1G37 tRNA modification neutralizes differential proline codon decoding, and its absence requires a minor isoacceptor for E. coli viability.

This study shows that loss of N1-methylation of G37 in tRNA causes ribosome stalling and alters gene expression, resembling the stringent response.

This study analyzes nasopharyngeal samples from COVID-19 patients and healthy controls to identify how SARS-CoV-2 infection affects respiratory epithelial cells and immune responses, finding impaired local intrinsic immunity in severe cases.

This study elucidates the mechanism of +1-frameshifting by tRNA SufB2, showing it uses triplet-slippage and ribosome conformational changes to decode quadruplet codons for genome recoding.