Author

T. de Neergaard

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:host-pathogen & immune response· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Assay:flow cytometry· 1

Frequent Co-Authors

P. Nordenfelt· 4 shared V. Kumra Ahnlide· 3 shared H. Khakzad· 2 shared M. Sundwall· 2 shared A. Bläckberg· 1 shared D. Tang· 1 shared E. Bratanis· 1 shared H. Ivarsson· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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4 shared papersImmunology

P. Nordenfelt

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Invasive streptococcal infection can lead to the generation of cross-strain opsonic antibodies

T. de Neergaard, A. Bläckberg, H. Ivarsson, S. Thomasson, V. Kumra Ahnlide, S. Chowdhury, H. Khakzad, J. Malmström, M. Rasmussen, P. Nordenfelt

This study examines opsonic antibody responses to invasive S. pyogenes infections, finding modest increases in antibody binding and variable opsonic capacity across strains.

bioRxiv · Jun 27, 2022Immunology

A human monoclonal antibody bivalently binding two different epitopes in streptococcal M protein protects against infection

W. Bahnan, L. Happonen, H. Khakzad, V. Kumra Ahnlide, T. de Neergaard, S. Wrighton, O. Andre, E. Bratanis, D. Tang, T. Hellmark, L. Bjorck, O. Shannon, L. Malmstrom, J. Malmstrom, P. Nordenfelt

The paper describes a human monoclonal antibody that binds two distinct epitopes on streptococcal M protein via a bivalent dual-Fab cis mode, providing protection against infection.

bioRxiv · Mar 1, 2021 · PreprintImmunology

A predictive model of antibody binding in the presence of IgG-interacting bacterial surface proteins

V. Kumra Ahnlide, T. de Neergaard, M. Sundwall, T. Ambjörnsson, P. Nordenfelt

The paper develops a biophysical model to predict antibody binding interactions with bacterial surface proteins and demonstrates its utility in predicting IgG treatment effects.

bioRxiv · Oct 20, 2020Microbiology

High-sensitivity assessment of phagocytosis by persistent association-based normalization

T. de Neergaard, M. Sundwall, P. Nordenfelt

This paper introduces a method to assess phagocytosis using persistent prey-phagocyte association, showing improved robustness, sensitivity, and reproducibility compared to standard methods.

bioRxiv · Nov 1, 2019Cell Biology