Opsonization by non-neutralizing antibodies can confer protection to SARS-CoV-2 despite Spike-dependent modulation of phagocytosis
W. Bahnan, S. Wrighton, M. Sundwall, A. Bläckberg, O. Larsson, U. Höglund, H. Khakzad, M. Godzwon, M. Walle, E. Elder, L. Happonen, O. Andre, J. Kumra Ahnlide, T. Hellmark, V. Wendel-Hansen, , P. Nordenfelt
This study shows that non-neutralizing Spike-specific antibodies can enhance phagocytosis of SARS-CoV-2 by monocytes, potentially offering protection despite not neutralizing the virus.
bioRxiv · Oct 14, 2021Immunology