Author

S. Wrighton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:human· 3 Assay:proteomics· 3 Organism:mouse· 1

Frequent Co-Authors

P. Nordenfelt· 4 shared W. Bahnan· 4 shared H. Khakzad· 3 shared L. Happonen· 3 shared O. Andre· 3 shared D. Tang· 2 shared E. Bratanis· 2 shared J. Malmström· 2 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersImmunology

P. Nordenfelt

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4 papers

Recent·Most cited

The increased hinge flexibility of an IgG1-IgG3 hybrid monoclonal enhances Fc-mediated protection against group A streptococci

A. Izadi, Y. Karami, E. Bratanis, S. Wrighton, H. Khakzad, M. Nyblom, B. Olofsson, L. Happonen, D. Tang, M. Nilges, J. Malmström, W. Bahnan, O. Shannon, L. Malmström, P. Nordenfelt

This study shows that increasing Fc flexibility in an IgG1-IgG3 hybrid monoclonal antibody enhances opsonic function and protection against group A streptococci.

bioRxiv · Oct 14, 2023 · PreprintImmunology

Group A streptococci induce high-affinity M protein-fibronectin interaction when specific human antibodies are bound

S. Wrighton, V. Kumra Ahnlide, O. Andre, W. Bahnan, P. Nordenfelt

The paper shows that human antibodies can enhance the Fn-binding affinity of GAS M proteins by targeting a conserved region, allowing bacteria to bind Fn more efficiently without producing additional proteins.

bioRxiv · May 4, 2022 · PreprintImmunology

Opsonization by non-neutralizing antibodies can confer protection to SARS-CoV-2 despite Spike-dependent modulation of phagocytosis

W. Bahnan, S. Wrighton, M. Sundwall, A. Bläckberg, O. Larsson, U. Höglund, H. Khakzad, M. Godzwon, M. Walle, E. Elder, L. Happonen, O. Andre, J. Kumra Ahnlide, T. Hellmark, V. Wendel-Hansen, , P. Nordenfelt

This study shows that non-neutralizing Spike-specific antibodies can enhance phagocytosis of SARS-CoV-2 by monocytes, potentially offering protection despite not neutralizing the virus.

bioRxiv · Oct 14, 2021Immunology

A human monoclonal antibody bivalently binding two different epitopes in streptococcal M protein protects against infection

W. Bahnan, L. Happonen, H. Khakzad, V. Kumra Ahnlide, T. de Neergaard, S. Wrighton, O. Andre, E. Bratanis, D. Tang, T. Hellmark, L. Bjorck, O. Shannon, L. Malmstrom, J. Malmstrom, P. Nordenfelt

The paper describes a human monoclonal antibody that binds two distinct epitopes on streptococcal M protein via a bivalent dual-Fab cis mode, providing protection against infection.

bioRxiv · Mar 1, 2021 · PreprintImmunology