Group A streptococci induce high-affinity M protein-fibronectin interaction when specific human antibodies are bound
S. Wrighton, V. Kumra Ahnlide, O. Andre, W. Bahnan, P. Nordenfelt
The paper shows that human antibodies can enhance the Fn-binding affinity of GAS M proteins by targeting a conserved region, allowing bacteria to bind Fn more efficiently without producing additional proteins.
bioRxiv · May 4, 2022 · PreprintImmunology