Author

D. Tang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Plant Biology· 3 Biochemistry· 2 Cancer Biology· 2 Microbiology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 10 Organism:human· 8 Approach:statistical model· 6 Research Focus:host-pathogen & immune response· 5 Research Focus:cell type annotation· 4 Research Focus:differential expression· 3 Assay:proteomics· 3 Organism:bacteria (other)· 2

Frequent Co-Authors

L. Happonen· 3 shared L. Wang· 3 shared Z. Li· 3 shared E. Bratanis· 2 shared H. Khakzad· 2 shared J. Liu· 2 shared J. Malmström· 2 shared L. Jiang· 2 shared

Activity by Year

2019-2025 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersImmunology

L. Happonen

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16 papers

Recent·Most cited

Single-cell profiling reveals the intratumor heterogeneity and immunosuppressive microenvironment in cervical adenocarcinoma

Y. Peng, J. Yang, J. Ao, Y. Li, J. Shen, X. He, D. Tang, C. Chu, C. Liu, L. Weng

This study uses single-cell RNA sequencing to identify unique cell clusters and immunosuppressive features in cervical adenocarcinoma compared to squamous cell carcinoma.

eLife · Mar 11, 2025Peer-reviewedCancer Biology

Avirulence depletion assay: combining R gene-mediated selection with bulk sequencing for rapid avirulence gene identification in wheat powdery mildew

L. Kunz, J. Jigisha, F. Menardo, A. G. Sotiropoulos, H. Zbinden, S. Zou, D. Tang, R. Hueckelhoven, B. Keller, M. C. Mueller

bioRxiv · Jul 10, 2024Plant Biology

Phase-separating MoSpa2 Complex Organizes Actin Nucleation Center for M.oryzae Plant Infection

D. He, Y.-B. Li, Q. Ma, L.-B. Han, D. Tang, Y. Miao

This study identifies MoSpa2's role in organizing actin nucleation centers in Magnaporthe oryzae through phase separation, supporting polarized growth and host infection.

bioRxiv · May 31, 2024 · PreprintPathology

Multi-Modal Mass Spectrometry Identifies a Conserved Protective Epitope in S. pyogenes Streptolysin O

D. Tang, C. A. Gueto-Tettay, E. Hjortswang, J. Ströbaek, S. Ekström, L. Happonen, L. Malmström, J. Malmström

This study uses multi-modal mass spectrometry to identify a conserved protective epitope in Streptolysin O from S. pyogenes, which could inform vaccine and therapeutic development.

bioRxiv · Dec 2, 2023 · PreprintBiochemistry

The increased hinge flexibility of an IgG1-IgG3 hybrid monoclonal enhances Fc-mediated protection against group A streptococci

A. Izadi, Y. Karami, E. Bratanis, S. Wrighton, H. Khakzad, M. Nyblom, B. Olofsson, L. Happonen, D. Tang, M. Nilges, J. Malmström, W. Bahnan, O. Shannon, L. Malmström, P. Nordenfelt

This study shows that increasing Fc flexibility in an IgG1-IgG3 hybrid monoclonal antibody enhances opsonic function and protection against group A streptococci.

bioRxiv · Oct 14, 2023 · PreprintImmunology

Progressive community, biogeochemical and evolutionary remodeling of the soil microbiome underpins long-term desert ecosystem restoration

Q. Chen, M. Yuan, L. Jiang, X. Wei, Z. Liu, C. Peng, Z. Huang, D. Tang, X. Wu, J. Sun, Q. Liu, X. Zhu, P. Gao, L. Huang, M. Wang, , C. Jiang

This study examines the long-term microbial changes in desert soil during ecological restoration, finding shifts in community structure, functional diversity, and biogeochemical cycles over 17 years.

bioRxiv · Sep 26, 2023 · PreprintMicrobiology

SARS-CoV-2 infected cells sprout actin-rich filopodia that facilitate viral invasion

Y. Jiu, Y. Zhang, X. Zhang, Z. Li, H. Yang, D. Tang, S. Zhao, Q. Zhang, B. Li, P. Lappalainen, Z. Cui, H. Liu, H. Li, W. Zhao

This study shows SARS-CoV-2 uses actin-rich filopodia for efficient viral entry, revealing two modes of entry and identifying potential antiviral targets.

bioRxiv · Oct 19, 2022 · PreprintCell Biology

An environmentally responsive transcriptional state modulates cell identities during root development

M. Oliva, T. Stuart, D. Tang, J. Pflueger, D. Poppe, J. S. Jabbari, S. Gigante, J. M. Dragwidge, J. Whelan, M. G. Lewsey, R. Lister

This study identifies an environmentally responsive transcriptional state that influences cell identities during root development in Arabidopsis, revealing a new layer of patterning independent of ontogenetic trajectories.

bioRxiv · Mar 4, 2022 · PreprintPlant Biology

A human monoclonal antibody bivalently binding two different epitopes in streptococcal M protein protects against infection

W. Bahnan, L. Happonen, H. Khakzad, V. Kumra Ahnlide, T. de Neergaard, S. Wrighton, O. Andre, E. Bratanis, D. Tang, T. Hellmark, L. Bjorck, O. Shannon, L. Malmstrom, J. Malmstrom, P. Nordenfelt

The paper describes a human monoclonal antibody that binds two distinct epitopes on streptococcal M protein via a bivalent dual-Fab cis mode, providing protection against infection.

bioRxiv · Mar 1, 2021 · PreprintImmunology

Deep mining of early antibody response in COVID-19 patients yields potent neutralisers and reveals high level of convergence

G. Bullen, J. D. Galson, P. Villar, L. Moreels, L. Ledsgaard, G. Mattiuzzo, G. Hall, E. M. Bentley, E. W. Masters, D. Tang, S. Millett, D. Tongue, R. Brown, I. Diamantopoulos, K. Parthiban, , A. Karatt-Vellatt

The paper identifies potent neutralising antibodies from early COVID-19 patient samples and shows high convergence in antibody sequences across studies.

bioRxiv · Dec 29, 2020 · PreprintImmunology

A Prediction Tool for Plaque Progression Based on Patient-specific Multi-Physical Modeling

J. Pan, Y. Cai, L. Wang, A. Maehara, G. Mintz, D. Tang, Z. Li

This paper develops a prediction tool for atherosclerotic plaque progression using patient-specific multi-physical modeling and microenvironmental indicators to differentiate stable from unstable plaques.

bioRxiv · Sep 17, 2020Bioengineering

Cryo-EM structure of C9ORF72-SMCR8-WDR41 reveals the role as a GAP for Rab8a and Rab11a

D. Tang, L. Xu, J. Sheng, X. Zhan, J. Liu, H. Jiang, X. Shu, X. Liu, T. Zhang, L. Jiang, C. Zhou, W. Li, W. Cheng, Z. Li, K. Wang, , S. Qi

This paper reports the cryo-EM structure of the C9ORF72-SMCR8-WDR41 complex, revealing its role as a GAP for Rab8a and Rab11a.

bioRxiv · Apr 16, 2020Biochemistry

Aging immune system-related blood cell DNA methylation can predict the onset of early stage colorectal cancer

Y. Quan, F. Liang, D. Wu, X. Yao, Y. Zhu, Y. Chen, A. Wu, D. Tang, B. Huang, R. Xu, Z. Lyu, Q. Yan, Z. Ning, Y. Li, J. Xiong

This study identifies DNA methylation of DZIP3 as a marker for early stage colorectal cancer, linked to aging and immune cell composition.

bioRxiv · Jan 13, 2020 · PreprintCancer Biology

Identification of QTL for leaf angle at canopy-wide levels in maize

D. Tang, Z. Chen, Q. JIang, J. Ni, P. Li, L. Wang, J. Zhou, C. Li, J. Liu

The paper identifies dozens of QTL for leaf angle across eight leaves in maize under three environments, revealing genetic architecture differences at various canopy levels.

bioRxiv · Jan 13, 2020Plant Biology

Pharmacokinetics Modeling and Simulation of Voriconazole Dosing and Safety in Patients with Liver Cirrhosis

T. Wang, M. Yan, D. Tang, Y. Dong, L. Zhu, Q. Du, D. Sun, J. Xing, Y. Dong

This study models voriconazole pharmacokinetics in cirrhotic patients and recommends reduced dosing for Child-Pugh C patients to improve safety.

bioRxiv · Feb 28, 2019 · PreprintPharmacology & Toxicology

Bacterial Glycogen as a Durable Energy Reserve Contributing to Persistence: An Updated Bibliography and Mathematical Model

L. Wang, Q. Liu, X. Tan, T. Yang, D. Tang, W. Wang, M. Wise

The paper reviews recent studies on bacterial glycogen as a durable energy reserve and presents a mathematical model to explain its role in bacterial persistence.

bioRxiv · Feb 4, 2019 · PreprintMicrobiology