Non-canonical HIF-1 stabilization is essential for intestinal tumorigenesis
N. Rohwer, S. Jumpertz, M. Erdem, A. Egners, K. T. Warzecha, A. Fragoulis, A. A. Kuehl, R. Kramann, S. Neuss, I. Rudolph, T. Endermann, C. Zasada, I. Apostolova, M. Gerling, S. Kempa, , T. Cramer
This study shows that non-canonical HIF-1 stabilization is crucial for intestinal tumorigenesis, independent of hypoxia, by affecting both epithelial and microenvironmental oncogenic processes.
bioRxiv · Feb 28, 2018Cancer Biology