F. Tacke

Delineating the heterogeneity of senescence-induced-functional alterations inhepatocytes

This study investigates how different stressors induce distinct senescence markers and bioenergetic changes in mouse hepatocytes and liver organoids.

Fluorochrome-dependent specific changes in spectral profiles using different compensation beads or human cells in full spectrum cytometry

This study evaluates compensation beads and human/murine cells as reference controls for full spectrum cytometry, showing fluorochrome-specific spectral profile differences.

Neonatal Peyer's patch cDC activation as a pacemaker of postnatal immune maturation

This study identifies neonatal Peyer's patch mononuclear phagocytes as a key driver of postnatal immune maturation and shows that targeted interventions can modulate mucosal immune responses.

Resolving the fibrotic niche of human liver cirrhosis using single-cell transcriptomics

This study uses single-cell transcriptomics to identify novel fibrotic cell types and interactions in human liver cirrhosis, revealing potential therapeutic targets.

Non-canonical HIF-1 stabilization is essential for intestinal tumorigenesis

This study shows that non-canonical HIF-1 stabilization is crucial for intestinal tumorigenesis, independent of hypoxia, by affecting both epithelial and microenvironmental oncogenic processes.