Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15
T. Faust, H. Yoon, R. P. Nowak, K. A. Donovan, Z. Li, Q. Cai, N. A. Eleuteri, T. Zhang, N. S. Gray, E. S. Fischer
The paper reveals how E7820 promotes RBM39 degradation via DCAF15 by binding to a non-conserved pocket on DCAF15, bypassing the need for high-affinity ligands.
bioRxiv · Aug 16, 2019Biochemistry