Q. Cai

On the discovered Cancer Driving Nucleotides (CDNs)-Distributions across genes, cancer types and patients

This study identifies Cancer Driving Nucleotides (CDNs) across cancer types and patients, finding that most remain unidentified and highlights the need for larger sample sizes to improve detection.

Aeromonas hydrophila CobQ is a new type of NAD+- and Zn2+-independent protein lysine deacetylase

This paper identifies AhCobQ as a novel NAD+- and Zn2+-independent lysine deacetylase in Aeromonas hydrophila with unique domain and substrate specificity.

Glioblastoma Margin as a Diffusion Barrier Revealed by Photoactivation of Plasmonic Nanovesicles

This study uses plasmonic nanovesicles to measure diffusion in GBM and finds the tumor margin has the lowest diffusion coefficient, indicating it acts as a diffusion barrier.

Trogocytosis of cancer-associated fibroblasts promotes pancreatic cancer growth and immune suppression via phospholipid scramblase anoctamin 6 (ANO6).

This study identifies ANO6-mediated trogocytosis as a mechanism by which CAFs transfer lipids to PDAC cells, promoting tumor growth and immune suppression.

Manipulation of Bacterial ROS Production Leads to Self-escalating DNA Damage and Resistance-resistant Lethality for Intracellular Mycobacteria

This study develops a resistance-resistant antimicrobial by inducing catastrophic DNA damage in intracellular mycobacteria through a hybrid organoruthenium-natural product that manipulates bacterial ROS production.

The effect of circulation rate on the water quality of container-type recirculation aquaculture system under different feeding rates of Schizothorax wangchiachii

This study examines how circulation rates affect water quality in a recirculation aquaculture system with varying feeding rates of Schizothorax wangchiachii, finding optimal circulation rates for different feed levels.

Fungal small RNAs ride in extracellular vesicles to enter plant cells through clathrin-mediated endocytosis

This study shows fungal small RNAs are secreted via extracellular vesicles and enter plant cells through clathrin-mediated endocytosis, using BcPLS1 as an EV biomarker.

A Conserved Requirement for RME-8/DNAJC13 in Neuronal Autolysosome Reformation

This study identifies RME-8/DNAJC13 as a conserved factor required for autolysosome reformation in neurons, linking it to autophagic flux and neurodegenerative disease mechanisms.

Botrytis cinerea small RNAs are associated with tomato AGO1 and silence tomato defense-related target genes supporting cross-kingdom RNAi

The paper reanalyzes existing data to show cross-kingdom RNAi between Botrytis cinerea and tomato, contradicting a previous study.

Optical Modulation of Blood-Brain-Tumor Barrier Permeability Enhances Drug Delivery in Diverse Preclinical Glioblastoma Models

This study demonstrates that optical modulation of the blood-brain-tumor barrier enhances drug delivery and suppresses tumor growth in glioblastoma models.

Calcium-Mediated Modulation of Blood-Brain Barrier Permeability by Laser Stimulation of Endothelial-Targeted Nanoparticles

This study investigates how laser stimulation of endothelial-targeted nanoparticles increases blood-brain barrier permeability through calcium signaling and cytoskeletal changes.

Methodological guidelines for isolation and purification of plant extracellular vesicles

This study compares two methods for isolating plant extracellular vesicles and recommends a detailed protocol for Arabidopsis thaliana, including differential ultracentrifugation and immunoaffinity capture for purification.

Human colorectal pre-cancer atlas identifies distinct molecular programs underlying two major subclasses of pre-malignant tumors

The paper creates a single-cell atlas of colorectal pre-cancerous polyps, identifying distinct molecular programs in adenomas and sessile serrated lesions and their associations with CRC subtypes.

Oncogenic Activation of AKT by MAPK6

This study shows that MAPK6 activates AKT to promote cancer, leading to oncogenic outcomes and poor patient survival in multiple cancers.

The S1/S2 boundary of SARS-CoV-2 spike protein modulates cell entry pathways and transmission

This study shows that the S1/S2 boundary of the SARS-CoV-2 spike protein affects cell entry and transmission by altering the pathway used for viral entry.

How do we segment text? Two-stage chunking operation in reading

This study investigates chunking mechanisms in reading by analyzing lexical decision times and EEG responses to Chinese strings with varying chunk structures, finding that global chunks are processed before local chunks.

Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15

The paper reveals how E7820 promotes RBM39 degradation via DCAF15 by binding to a non-conserved pocket on DCAF15, bypassing the need for high-affinity ligands.

Analysis of the Mutant Selection Window and Killing of Mycoplasma hyopneumoniae for Doxycycline, Tylosin, Danofloxacin, Tiamulin, and Valnemulin

This study evaluates the mutant selection window and killing effects of five antibiotics against Mycoplasma hyopneumoniae, finding that danofloxacin, tylosin, and doxycycline are more likely to promote resistance than tiamulin and valnemulin.