H. Yoon

Biologically-informed deep neural networks provide quantitative assessment of intratumoral heterogeneity in post-treatment glioblastoma

This paper develops BioNet, a biologically-informed deep learning model, to predict intratumoral heterogeneity in post-treatment glioblastoma using MRI and biopsy data, showing improved performance over existing methods.

Combined Partial-Nitrification and Phosphorus Removal with the co-existence of Nitrite-resistant phosphorous accumulating organisms (PAOs) and nitrifiers in the treatment of high-strength manure digestate

This study demonstrates the coexistence of nitrite-resistant PAOs and nitrifiers in a reactor treating manure digestate, achieving efficient nitrogen and phosphorus removal through optimized aeration schemes.

Single-cell RNA sequencing reveals characteristics of myeloid cells in pulmonary post-acute sequelae of SARS-CoV-2

This study uses single-cell RNA sequencing to analyze myeloid cells in PBMCs from PPASC patients and controls, identifying increased myeloid lineage cells and altered gene expression linked to fibrosis and immune suppression.

A developmentally-inspired hypoxia condition promotes kidney organoid differentiation from human pluripotent stem cells

This study uses hypoxia to improve kidney organoid differentiation from hPSCs, resulting in more mature structures with collecting ducts and potential for disease modeling.

FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity

FALCON systematically analyzes 61 free fatty acids to identify lipotoxic effects and a novel mediator of lipotoxicity, CMIP, in human pancreatic beta cells.

Template-assisted covalent modification of DCAF16 underlies activity of BRD4 molecular glue degraders

This paper describes a new mechanism for molecular glue degraders called template-assisted covalent modification, showing how BRD4 degraders recruit CUL4DCAF16 to degrade BRD4.

Ptr1 and ZAR1 immune receptors confer overlapping and distinct bacterial pathogen effector specificities

The paper identifies effector recognition specificities of NbPtr1 and NbZAR1 in N. benthamiana and shows their distinct and overlapping roles in detecting bacterial effectors.

Change in protein, oil and fatty acid contents in soybeans (Glycine max (L.) Merr.) of different seed coat colors and seed weight

This study analyzes the effects of seed coat color and seed weight on protein, oil, and fatty acid contents in soybean germplasms, finding significant variations in fatty acids and a trade-off between oleic and linoleic acids.

SARS-CoV-2 variant B.1.1.7 is susceptible to neutralizing antibodies elicited by ancestral Spike vaccines

This study shows that B.1.1.7 SARS-CoV-2 variant remains neutralizable by antibodies from ancestral Spike vaccines and convalescent sera, though with reduced efficacy.

Physiological role of the 3'IgH CBEs super-anchor in antibody class switching

The paper shows that deleting all 3IgH CBEs affects germline transcription and CSR of upstream S regions, except S{gamma}1, and causes aberrant CSR rearrangements.

Spike mutation pipeline reveals the emergence of a more transmissible form of SARS-CoV-2

The paper develops a pipeline to track SARS-CoV-2 mutations in the Spike protein, identifying D614G as a rapidly spreading mutation with potential implications for transmission and immune evasion.

Quantification of nosZ genes and transcripts in activated sludge microbiomes with novel group-specific qPCR methods validated with metagenomic analyses

The paper develops and validates group-specific qPCR methods for quantifying nosZ genes and transcripts in activated sludge microbiomes using metagenomic analysis.

PHD3 controls energy homeostasis and exercise capacity.

The paper was submitted in error and the authors do not wish it to be cited.

Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15

The paper reveals how E7820 promotes RBM39 degradation via DCAF15 by binding to a non-conserved pocket on DCAF15, bypassing the need for high-affinity ligands.