BiochemistrybioRxiv
Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15
T. Faust, H. Yoon, R. P. Nowak…·E. S. Fischer
The paper reveals how E7820 promotes RBM39 degradation via DCAF15 by binding to a non-conserved pocket on DCAF15, bypassing the need for high-affinity ligands.
DOI 10.1038/s41589-019-0378-3