Author

T. Gidalevitz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 2

Signature Assays, Organisms & Methods

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Organism:C. elegans· 3 Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:development & morphogenesis· 2 Approach:genetic perturbation / CRISPR· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

M. Ying· 2 shared Y. Argon· 2 shared A. W. Paton· 1 shared C. Akay-Espinoza· 1 shared C.-C. A. Hu· 1 shared C.-H. A. Tang· 1 shared D. Blumenthal· 1 shared D. C. Brady· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersCell Biology

M. Ying

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

The RIDD activity of C. elegans IRE1 modifies neuroendocrine signaling in anticipation of environment stress to ensure survival

M. Ying, Y. Argon, T. Gidalevitz

This study shows that C. elegans IRE1's RIDD activity degrades DAF-7 mRNA in response to low-level ER stress, signaling environmental danger to enhance survival.

bioRxiv · Aug 10, 2023 · PreprintCell Biology

PERK Kinase Activity is Regulated by Copper Binding-A New Regulatory Paradigm for Modulation of ER Stress Tolerance

S. E. B. Newton, N. R. Beratan, C. Akay-Espinoza, M. K. Bond, X. Shi, J. Perhacs, T. Gidalevitz, D. C. Brady, K. L. Jordan-Sciutto

The paper shows copper binding regulates PERK kinase activity, affecting ER stress tolerance in C. elegans.

bioRxiv · Sep 2, 2022Biochemistry

The interdomain helix between the kinase and RNase domains of IRE1α transmits the conformational change that underlies ER stress-induced activation.

D. Ricci, S. Tutton, I. Marrocco, M. Ying, D. Blumenthal, D. Eletto, J. Vargas, S. Boyle, H. Fazelinia, J. C. Paton, A. W. Paton, C.-H. A. Tang, C.-C. A. Hu, T. Gidalevitz, Y. Argon

This study identifies the interdomain helix between IRE1α kinase and RNase domains as critical for transmitting conformational changes during ER stress, revealing its role in regulating oligomerization, RNase activity, and kinase function.

bioRxiv · Jan 14, 2020 · PreprintBiochemistry

HSP-4/BiP expression in secretory cells is regulated by a lineage-dependent differentiation program and not by the unfolded protein response

J. Zha, J. Alexander-Floyd, T. Gidalevitz

The paper shows that HSP-4/BiP expression in secretory cells is lineage-dependent and not controlled by the UPR, using C. elegans as a model.

bioRxiv · Aug 9, 2018Cell Biology