Author

S. Boyle

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Cancer Biology· 2 Biochemistry· 1 Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 5 Research Focus:cell signaling & trafficking· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Assay:ChIP-seq· 2 Research Focus:chromatin & epigenetic regulation· 2 Organism:mouse· 2

Frequent Co-Authors

I. Tempera· 2 shared L. B. Caruso· 2 shared A. Buckle· 1 shared A. Cobernuss-Rahn· 1 shared A. J. Dafferner· 1 shared A. Kossenkov· 1 shared A. Quintanilla· 1 shared A. W. Paton· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 7 mutual co-author links

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2 shared papersMicrobiology

I. Tempera

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

TPR is required for cytoplasmic chromatin fragment formation during senescence

B. M. Bartlett, Y. Kumar, S. Boyle, T. Chowdhury, A. Quintanilla, C. Boumendil, J. C. Acosta, W. A. Bickmore

The paper shows TPR is required for early NF-κB activation during oncogene-induced senescence, leading to cytoplasmic chromatin fragment formation and SASP activation.

bioRxiv · Apr 18, 2024Cell Biology

Androgen-mediated TGFβ expression suppresses anti-tumor neutrophil response in bone metastatic prostate cancer

M. Alsamraae, D. Costanzo-Garvey, B. A. Teply, S. Boyle, G. Sommerville, Z. Herbert, C. Morrissey, A. J. Dafferner, M. Y. Abdalla, R. W. Fallet, T. Kielian, H. Jensen-Smith, E. I. deOliveira, K. Chen, I. A. Bettencourt, , L. M. Cook

This study identifies androgen-mediated TGFβ expression as a mechanism suppressing anti-tumor neutrophil response in bone metastatic prostate cancer and shows that combining ADT with TGFβ receptor inhibition restores neutrophil cytotoxicity.

bioRxiv · Dec 30, 2022 · PreprintCancer Biology

Multi-site Performance Evaluation of the cobas 5800 System and Comparison to the cobas 6800/8800 Systems for Quantitative Measurement of HBV, HCV, and HIV-1 Viral Load.

J. Tschape, A. Cobernuss-Rahn, S. Boyle, N. T. Parkin, B. LaBrot, S. Aslam, S. Young, P. Gohl

This study compares the performance of the cobas 5800 system to the cobas 6800/8800 systems for viral load measurement of HBV, HCV, and HIV-1 across multiple sites, finding high correlation and acceptable variability.

bioRxiv · Aug 9, 2022Microbiology

Transcription modulates chromatin dynamics and locus configuration sampling

G. Forte, A. Buckle, S. Boyle, D. Marenduzzo, N. Gilbert, C. A. Brackley

The paper uses simulations and experiments to show transcription affects chromatin dynamics and locus configurations in mouse cells.

bioRxiv · Nov 8, 2021Biophysics

The Nuclear Lamina binds the EBV genome during latency and regulates viral gene expression

L. B. Caruso, R. Guo, K. Keith, J. Madzo, D. Maestri, S. Boyle, J. Wasserman, A. Kossenkov, B. Gewurz, I. Tempera

bioRxiv · Aug 5, 2021Microbiology

The interdomain helix between the kinase and RNase domains of IRE1α transmits the conformational change that underlies ER stress-induced activation.

D. Ricci, S. Tutton, I. Marrocco, M. Ying, D. Blumenthal, D. Eletto, J. Vargas, S. Boyle, H. Fazelinia, J. C. Paton, A. W. Paton, C.-H. A. Tang, C.-C. A. Hu, T. Gidalevitz, Y. Argon

This study identifies the interdomain helix between IRE1α kinase and RNase domains as critical for transmitting conformational changes during ER stress, revealing its role in regulating oligomerization, RNase activity, and kinase function.

bioRxiv · Jan 14, 2020 · PreprintBiochemistry

Epstein-Barr virus-encoded latent membrane protein 1 and B-cell growth transformation induces lipogenesis through fatty acid synthase.

M. Hulse, S. Johnson, S. Boyle, L. B. Caruso, I. Tempera

This paper shows that Epstein-Barr virus's LMP1 protein promotes B-cell transformation by inducing fatty acid synthesis and lipid droplet formation, suggesting lipogenesis inhibitors could treat LMP1-positive EBV-related cancers.

bioRxiv · Dec 15, 2019Microbiology

Detection of ctDNA from dried blood spots after DNA size selection

K. Heider, J. C. Wan, J. Hall, S. Boyle, I. Hudecova, D. Gale, W. N. Cooper, P. G. Corrie, J. D. Brenton, C. G. Smith, N. Rosenfeld

This paper develops a protocol to detect ctDNA from dried blood spots using low-depth WGS and fragment size selection, showing its feasibility in human and mouse models.

bioRxiv · Sep 5, 2019Cancer Biology