Author

D. Blumenthal

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1

Frequent Co-Authors

J. K. Burkhardt· 2 shared A. Buffone· 1 shared A. W. Paton· 1 shared B. Huang· 1 shared C.-C. A. Hu· 1 shared C.-H. A. Tang· 1 shared D. A. Hammer· 1 shared D. Eletto· 1 shared

Activity by Year

2020-2020 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersCell Biology

J. K. Burkhardt

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

LFA-1 signals to promote actin polymerization and upstream migration in T cells

N. H. Roy, S. H. Kim, A. Buffone, D. Blumenthal, B. Huang, S. Agarwal, P. L. Schwartzberg, D. A. Hammer, J. K. Burkhardt

This study shows that LFA-1 signaling, but not VLA-4, drives cytoskeletal changes enabling T cells to migrate upstream against shear flow.

bioRxiv · Apr 29, 2020Cell Biology

T cell priming is enhanced by maturation-dependent stiffening of the dendritic cell cortex

D. Blumenthal, V. Chandra, L. Avery, J. K. Burkhardt

This study shows that maturation increases dendritic cell cortical stiffness, which enhances T cell activation by reducing agonist dose requirements and is more pronounced in CD4+ T cells.

bioRxiv · Feb 16, 2020Immunology

The interdomain helix between the kinase and RNase domains of IRE1α transmits the conformational change that underlies ER stress-induced activation.

D. Ricci, S. Tutton, I. Marrocco, M. Ying, D. Blumenthal, D. Eletto, J. Vargas, S. Boyle, H. Fazelinia, J. C. Paton, A. W. Paton, C.-H. A. Tang, C.-C. A. Hu, T. Gidalevitz, Y. Argon

This study identifies the interdomain helix between IRE1α kinase and RNase domains as critical for transmitting conformational changes during ER stress, revealing its role in regulating oligomerization, RNase activity, and kinase function.

bioRxiv · Jan 14, 2020 · PreprintBiochemistry