M. Ying

Elucidating the kinetic and thermodynamic insight into regulation of glycolysis by lactate dehydrogenase and its impact on tricarboxylic acid cycle and oxidative phosphorylation in cancer cells

This study investigates how lactate dehydrogenase (LDH) regulates glycolysis, TCA cycle, and oxidative phosphorylation in cancer cells through kinetic and thermodynamic mechanisms, showing that LDH inhibition disrupts metabolic pathways and induces cell death under hypoxia.

The RIDD activity of C. elegans IRE1 modifies neuroendocrine signaling in anticipation of environment stress to ensure survival

This study shows that C. elegans IRE1's RIDD activity degrades DAF-7 mRNA in response to low-level ER stress, signaling environmental danger to enhance survival.

The thermodynamic state of aerobic glycolytic flux plays a critical role in stabilizing aerobic glycolytic flux of cancer cells

This study identifies the thermodynamic state of aerobic glycolysis (TSAG) as a system property that stabilizes glycolytic flux in cancer cells, showing it resists perturbations and requires both enzyme inhibition and TSAG disruption for effective AG inhibition.

The interdomain helix between the kinase and RNase domains of IRE1α transmits the conformational change that underlies ER stress-induced activation.

This study identifies the interdomain helix between IRE1α kinase and RNase domains as critical for transmitting conformational changes during ER stress, revealing its role in regulating oligomerization, RNase activity, and kinase function.

Lactate dehydrogenases amplify reactive oxygen species in cancer cells in response to oxidative stimuli

This study shows lactate dehydrogenases (LDHA and LDHB) can both generate and prevent reactive oxygen species (ROS) in cancer cells, depending on oxidative stress levels.