Folding correctors can restore CFTR posttranslational folding landscape by allosteric domain-domain coupling
G. L. Lukacs, N. Soya, H. Xu, A. Roldan, Z. Yang, H. Ye, A. Premchandar, F. Jiang, G. Veit, S. P. C. Cole, J. C. Kappes, T. Hegedus
The paper shows that allosteric domain-domain coupling modulates the folding landscape of ABCC transporters, and that folding correctors can rescue misfolding by rewiring these networks.
bioRxiv · Oct 19, 2023Biophysics