Author

T. Lecomte

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

A. Robert· 2 shared C. Vandier· 2 shared D. Crottes· 2 shared J. Bourgeais· 2 shared J.-F. Dumas· 2 shared M. Gueguinou· 2 shared O. Herault· 2 shared W. Raoul· 2 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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2 shared papersCancer Biology

A. Robert

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2 papers

Recent·Most cited

Encoding of the colorectal cancer metabolic program through MICU2

A. Robert, D. Crottes, J. Bourgeais, N. Gueguen, A. Chevrollier, J.-F. Dumas, S. Servais, I. Domingo, S. Chadet, J. Sobilo, O. Herault, T. Lecomte, C. Vandier, W. Raoul, M. Gueguinou

This study investigates the role of MICU2 in colorectal cancer metabolism, showing its importance in mitochondrial function, metabolic flexibility, and tumor progression.

bioRxiv · Oct 31, 2023 · PreprintCancer Biology

Curcumin and NCLX Inhibitors Share Anti-Tumoral Mechanisms in Microsatellite-Instability-Driven Colorectal Cancer

M. Gueguinou, S. Ibrahim, J. Bourgeais, A. Robert, T. Pathak, X. Zhang, D. Crottes, J. Dupuy, D. Ternant, V. Monbet, R. Guibon, H. Flores-Romero, A. Lefevre, S. Lerondel, A. Le Pape, , T. Lecomte

This study identifies NCLX as a therapeutic target in MSI-driven CRC, showing that curcumin and NCLX inhibitors induce anti-tumoral effects through mitochondrial calcium overload and apoptosis.

bioRxiv · Jan 18, 2022Cancer Biology