Author

D. Crottes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

A. Robert· 3 shared C. Vandier· 3 shared M. Gueguinou· 3 shared G. Fromont-Hankard· 2 shared J. Bourgeais· 2 shared J.-F. Dumas· 2 shared O. Herault· 2 shared T. Lecomte· 2 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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3 shared papersCancer Biology

A. Robert

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Investigation of the heterogeneity of cancer cells using single cell calcium profiling.

A. Bura, C. Caussette, M. Gueguinou, D. Bellanger, A. Robert, M. Cancel, M. Lacouette-Rata, G. Fromont-Hankard, C. Vandier, K. Maheo, T. Brouard, D. Crottes

This study uses single cell calcium profiling combined with machine learning to analyze Ca2+ signature heterogeneity in cancer cells and their remodeling during resistance and cell interactions.

bioRxiv · Jan 14, 2024Cancer Biology

Encoding of the colorectal cancer metabolic program through MICU2

A. Robert, D. Crottes, J. Bourgeais, N. Gueguen, A. Chevrollier, J.-F. Dumas, S. Servais, I. Domingo, S. Chadet, J. Sobilo, O. Herault, T. Lecomte, C. Vandier, W. Raoul, M. Gueguinou

This study investigates the role of MICU2 in colorectal cancer metabolism, showing its importance in mitochondrial function, metabolic flexibility, and tumor progression.

bioRxiv · Oct 31, 2023 · PreprintCancer Biology

Curcumin and NCLX Inhibitors Share Anti-Tumoral Mechanisms in Microsatellite-Instability-Driven Colorectal Cancer

M. Gueguinou, S. Ibrahim, J. Bourgeais, A. Robert, T. Pathak, X. Zhang, D. Crottes, J. Dupuy, D. Ternant, V. Monbet, R. Guibon, H. Flores-Romero, A. Lefevre, S. Lerondel, A. Le Pape, , T. Lecomte

This study identifies NCLX as a therapeutic target in MSI-driven CRC, showing that curcumin and NCLX inhibitors induce anti-tumoral effects through mitochondrial calcium overload and apoptosis.

bioRxiv · Jan 18, 2022Cancer Biology

K2P channel C-type gating involves asymmetric selectivity filter order-disorder transitions

M. Lolicato, A. Natale, F. Aberemane-Ali, D. Crottes, S. Capponi, R. Duman, A. Wagner, J. M. Rosenberg, M. Grabe, D. L. Minor

This study identifies potassium-dependent conformational changes in K2P2.1 channels that underlie C-type gating, revealing asymmetric order-disorder transitions in the selectivity filter and adjacent loops.

bioRxiv · Mar 20, 2020Biophysics