Cancer BiologybioRxiv
Curcumin and NCLX Inhibitors Share Anti-Tumoral Mechanisms in Microsatellite-Instability-Driven Colorectal Cancer
M. Gueguinou, S. Ibrahim, J. Bourgeais…·T. Lecomte
This study identifies NCLX as a therapeutic target in MSI-driven CRC, showing that curcumin and NCLX inhibitors induce anti-tumoral effects through mitochondrial calcium overload and apoptosis.
DOI 10.1007/s00018-022-04311-4