Blocking Interleukin-1β transiently limits left ventricular dilation and reduces cardiac lymphangiogenesis during pressure-overload in mice
C. Heron, T. Lemarcis, O. Laguerre, M. Bundalo, C. Valentin, M. Valet, A. Dumesnil, J.-B. Michel, P. Mulder, A. Zernecke, V. Tardif San Martin, E. Brakenhielm
This study shows that blocking IL-1β early after pressure-overload reduces left ventricular dilation but not heart failure, while late blocking reduces lymphangiogenesis without worsening fibrosis.
bioRxiv · Apr 1, 2023 · PreprintPhysiology