Author

E. Brakenhielm

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:development & morphogenesis· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

A. Dumesnil· 3 shared C. Heron· 2 shared J.-B. Michel· 2 shared J.-P. Henry· 2 shared P. Mulder· 2 shared S. Fraineau· 2 shared S. Renet· 2 shared V. Richard· 2 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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3 shared papersPhysiology

A. Dumesnil

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

PhysiologyNature CommunicationsPeer-reviewedJul 25, 2023

Ezh2 as an epigenetic checkpoint regulator during monocyte differentiation: a potential target to improve cardiac repair after myocardial infarction

J. Rondeaux, D. Groussard, S. Renet…·S. Fraineau

This study shows that inhibiting EZH2 improves cardiac repair after myocardial infarction by enhancing monocyte repair functions and reducing cardiac dysfunction.

DOI 10.1038/s41467-023-40186-0

humanbulk RNA-seq

𝕏 PostBluesky

PhysiologybioRxivPreprintApr 1, 2023

Blocking Interleukin-1β transiently limits left ventricular dilation and reduces cardiac lymphangiogenesis during pressure-overload in mice

C. Heron, T. Lemarcis, O. Laguerre…·E. Brakenhielm

This study shows that blocking IL-1β early after pressure-overload reduces left ventricular dilation but not heart failure, while late blocking reduces lymphangiogenesis without worsening fibrosis.

DOI 10.1101/2023.04.01.535056

mousebulk RNA-seq

𝕏 PostBluesky

PhysiologybioRxivApr 27, 2021

Regulation and impact of cardiac lymphangiogenesis in pressure-overload-induced heart failure

C. Heron, A. Dumesnil, M. Houssari…·E. Brakenhielm

This study investigates cardiac lymphangiogenesis in pressure-overload-induced heart failure, finding that it limits inflammation and fibrosis, delaying heart failure development.

DOI 10.1093/cvr/cvac086

mousehuman

𝕏 PostBluesky