Gut bacterial metabolite Urolithin A (UA) mitigates Ca2+ 1 entry inT cells by regulating miR-10a-5p
S. Zhang, T. Maghout, H. Cao, L. Pelzl, M. Salkere, A. Cheng, F. Lang, Y. Singh
This study shows that gut metabolite UA reduces T cell proliferation by increasing miR-10a-5p and decreasing Orai1/STIM1/STIM2 expression and SOCE in murine CD4+ T cells.
bioRxiv · Jan 29, 2018Immunology