Cancer BiologybioRxivPreprint
EGFR Oncogenes Expressed In Glioblastoma Are Activated As Covalent Dimers And Paradoxically Stimulated By Erlotinib
E. Buck, M. O'Connor, D. Romashko…·J. Zhang
The paper identifies a mechanism by which extracellular domain EGFR mutations in glioblastoma are activated through covalent dimerization, rendering ATP-site inhibitors ineffective and paradoxically promoting proliferation.
DOI 10.1101/810721