Author

D. Epstein

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Immunology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2

Frequent Co-Authors

A. G. Freud· 2 shared B. Knott· 2 shared E. Wright· 2 shared M. Bell· 2 shared M. E. Greene· 2 shared P. M. Porrett· 2 shared R. Asiimwe· 2 shared S. C. Little· 2 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersImmunology

A. G. Freud

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Inhibition of NFAT promotes loss of tissue resident uterine natural killer cells and attendant pregnancy complications in humans

R. Asiimwe, B. Knott, M. E. Greene, E. Wright, M. Bell, D. Epstein, S. D. Yates, M. V. Gonzalez, S. Fry, E. Boydston, S. Clevenger, J. E. Locke, B. E. Brocato, C. M. Burgan, R. Burney, , P. M. Porrett

The paper identifies NFAT inhibition as a cause of reduced uterine natural killer (uNK) cells and pregnancy complications in humans through analysis of uterus transplant recipients.

bioRxiv · Mar 7, 2024 · PreprintImmunology

Sequential Transcriptional Programs of Tissue Residency Drive Human Uterine NK Cell Development

M. E. Greene, R. Asiimwe, E. Wright, M. Bell, D. Epstein, S. D. Yates, B. Knott, S. Fry, S. Clevenger, J. Locke, S. C. Little, H. Richter, A. G. Freud, P. M. Porrett

This study identifies sequential transcriptional programs of tissue residency driving human uterine NK cell development through single-cell analyses.

bioRxiv · Feb 29, 2024 · PreprintImmunology

TIAToolbox: An End-to-End Toolbox for Advanced Tissue Image Analytics

J. Pocock, S. Graham, Q. D. Vu, M. Jahanifar, S. Deshpande, G. Hadjigeorghiou, A. Shephard, R. M. S. Bashir, M. Bilal, W. Lu, D. Epstein, F. Minhas, N. Rajpoot, S. E. A. Raza

TIAToolbox provides an end-to-end Python toolbox for computational pathology, enabling efficient and accessible use of deep learning algorithms for tissue image analysis.

bioRxiv · Dec 23, 2021Bioengineering

The functional landscape of patient derived RNF43 mutations predicts Wnt inhibitor sensitivity

J. Yu, P. A. Bt Mohamed Yuso, P. Goh, N. P. HARMSTON, D. Epstein, D. M. Virshup, B. Madan

This study identifies RNF43 mutations that predict sensitivity to Wnt inhibitors by analyzing their functional impact in vitro and in vivo.

bioRxiv · Mar 25, 2020 · PreprintCancer Biology

EGFR Oncogenes Expressed In Glioblastoma Are Activated As Covalent Dimers And Paradoxically Stimulated By Erlotinib

E. Buck, M. O'Connor, D. Romashko, A. Salomatov, N. Ishiyama, D. Epstein, A. Mayweg, A. Flohr, R. Iacone, T. Nicolaides, S. Markovic, J. Zhang

The paper identifies a mechanism by which extracellular domain EGFR mutations in glioblastoma are activated through covalent dimerization, rendering ATP-site inhibitors ineffective and paradoxically promoting proliferation.

bioRxiv · Oct 21, 2019 · PreprintCancer Biology