Author

T. Schwede

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Bioinformatics· 2 Bioengineering· 1 Microbiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:deep learning· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:database / resource· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1

Frequent Co-Authors

J. Durairaj· 3 shared J. Pereira· 3 shared M. Akdel· 2 shared A. Andreeva· 1 shared A. Bateman· 1 shared A. Camus· 1 shared A. DellAglio· 1 shared A. Devaux· 1 shared

Activity by Year

2022-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersBioinformatics

J. Durairaj

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Structural implications of BK polyomavirus sequence variations in the major viral capsid protein Vp1 and large T-antigen: a computational study

J. Durairaj, O. Follonier, K. Leuzinger, L. T. Alexander, M. Wilhelm, J. Pereira, C. A. Hillenbrand, F. Weissbach, T. Schwede, H. H. Hirsch

This study analyzes BKPyV sequence variations in Vp1 and LTag using computational methods, finding high variability in Vp1 that may impact immune control and vaccine design, while LTag shows less variability but potential effects on T-cell epitopes.

bioRxiv · Dec 21, 2023Microbiology

Epitope Engineered Human Haematopoietic Stem Cells are Shielded from CD123-targeted Immunotherapy

R. Marone, E. Landmann, A. Devaux, R. Lepore, D. Seyres, J. Zuin, T. Burgold, C. Engdahl, G. Capoferri, A. DellAglio, C. Larrue, F. Simonetta, J. Rositzka, M. Rhiel, G. Andrieux, , L. T. Jeker

This paper shows that epitope-engineered human hematopoietic stem cells are protected from CD123-targeted immunotherapy while maintaining functionality, offering a strategy for tumor-selective therapy.

Journal of Experimental Medicine · Sep 29, 2023Peer-reviewedBioengineering

What is hidden in the darkness? Deep-learning assisted large-scale protein family curation uncovers novel protein families and folds

J. Durairaj, A. M. Waterhouse, T. Mets, T. Brodiazhenko, M. Abdullah, G. Studer, M. Akdel, A. Andreeva, A. Bateman, T. Tenson, V. Hauryliuk, T. Schwede, J. Pereira

This work uses deep learning to uncover novel protein families and folds by analyzing sequence and structural data, adding new entries to Pfam and identifying a novel toxin-antitoxin system.

bioRxiv · Mar 14, 2023 · PreprintBioinformatics

What is hidden in the darkness? Characterization of AlphaFold structural space.

J. Durairaj, J. Pereira, M. Akdel, T. Schwede

The paper analyzes over 200 million AlphaFold predicted protein structures using a shape-mer approach to identify novel structural compositions and potential functional annotations.

bioRxiv · Oct 11, 2022 · PreprintBioinformatics