Deletion of PI3-Kinase Promotes Myelodysplasia Through Dysregulation of Autophagy in Hematopoietic Stem Cells
K. Ames, I. Kaur, Y. Shi, M. M. Tong, T. Sinclair, S. Hemmati, S. G. Glushakow-Smith, E. E. Tein, L. Gurska, R. Dubin, J. Shan, K. Pradhan, A. Verma, C. Montagna, K. Gritsman
This study shows that deleting all three Class IA PI3K isoforms in HSCs leads to myelodysplasia through impaired autophagy, which affects differentiation and multilineage repopulation.
bioRxiv · Dec 4, 2020 · PreprintCancer Biology