Cancer BiologyNature CancerPeer-reviewed
Impaired Barrier Integrity of the Skeletal Muscle Vascular Endothelium Drives Progression of Cancer Cachexia
Y.-M. Kim, M. A. Sanborn, X. Wang…·J. Rehman
This study identifies impaired vascular endothelial integrity in skeletal muscle as a driver of cancer cachexia and shows that restoring endothelial PGC1 can prevent muscle loss.