J. Qiu

Discovery of a Heparan Sulfate Binding Domain in Monkeypox Virus H3 as an Anti-poxviral Drug Target Combining AI and MD Simulations

The paper identifies a conserved heparan sulfate binding domain in MPXV H3 using AI and MD simulations, validates its role in viral adhesion, and demonstrates a protein inhibitor that disrupts this interaction, inhibiting infection in vitro and in vivo.

Genetically Encoded FRET Biosensor for Live-cell Visualization of Lamin A Phosphorylation at Serine 22

This paper develops a FRET-based biosensor to visualize lamin A phosphorylation at Serine 22 in live cells, revealing its dynamics during the cell cycle and its role in nuclear envelope breakdown.

Targeting PRMT3 Impairs Methylation and Oligomerization of HSP60 to Boost Anti-Tumor Immunity by Activating cGAS/STING Signaling

This study identifies PRMT3 as a driver of immunotherapy resistance in HCC, showing that targeting it enhances anti-tumor immunity via cGAS/STING activation.

PHOSPHATE-INDUCED 1 and its paralogs positively regulate cellulose biosynthesis in Arabidopsis.

This study shows that PHOSPHATE-INDUCED 1 and its paralogs regulate cellulose biosynthesis in Arabidopsis by modulating CSC activity in response to developmental and environmental cues.

Biosynthesis of the proteins containing neurotoxin β-N-methylamino-L-alanine in marine diatoms

This study investigates how iron limitation increases BMAA-containing protein production in marine diatoms and identifies cysK as a key enzyme in BMAA biosynthesis.

Metformin and guanylurea reduce survival, but have limited sublethal effects in larval zebrafish (Danio rerio)

This study tests the effects of metformin and guanylurea on zebrafish larvae, finding increased mortality and spinal curvature at high concentrations but limited sublethal effects at environmentally relevant levels.

Identification of Host Restriction Factors Critical for Recombinant AAV Transduction of Polarized Human Airway Epithelium

This study identifies host restriction factors critical for rAAV2.5T transduction of polarized human airway epithelium, revealing KIAA0319L's role in transduction but not internalization, and WDR63's role in transduction without involvement in internalization or nuclear entry.

FAM210A mediates an inter-organelle crosstalk essential for protein synthesis and muscle growth in mouse

This study identifies FAM210A as a mediator of mitochondrial-ribosome crosstalk that supports protein synthesis and muscle growth in mice.

Chemical-guided SHAPE sequencing (cgSHAPE-seq) informs the binding site of RNA-degrading chimeras targeting SARS-CoV-2 5' untranslated region

The paper develops cgSHAPE-seq to identify RNA-binding sites of coumarin derivatives targeting SARS-CoV-2 5' UTR and demonstrates their use as RNA-degrading chimeras to reduce viral RNA expression.

Resolving the developmental mechanisms of coagulation abnormalities characteristic of SARS-CoV2 based on single-cell transcriptome analysis

This study uses single-cell transcriptome analysis to identify immune and metabolic mechanisms underlying coagulation abnormalities in SARS-CoV-2 infection.

Spatiotemporal cell landscape of human embryonic tooth development

The paper maps the spatiotemporal cell landscape of human embryonic tooth development using single-cell RNA sequencing and spatial transcriptomics, identifying key cell types and regulatory networks.

ALiCE: A versatile, high yielding and scalable eukaryotic cell-free protein synthesis (CFPS) system

This paper introduces ALiCE, a scalable eukaryotic cell-free protein synthesis system capable of producing complex proteins at high yields and demonstrating functional activity and post-translational modifications.

Microsecond pulse electrical stimulation modulates cell migration

This study introduces microsecond pulse electric field (sPEF) to enhance wound healing by promoting fibroblast migration and ECM alignment, validated in 2D and 3D models and a mouse wound healing assay.

Novel MBLs inhibitors screened from FDA-approved drug library restore the susceptibility of carbapenems to NDM-1-harbouring bacteria

The paper screens FDA-approved drugs to find inhibitors of NDM-1, restoring carbapenem efficacy against resistant bacteria.

Single-nucleus RNA Sequencing and Spatial Transcriptomics Reveal the Immunological Microenvironment of Cervical Squamous Cell Carcinoma

This study uses snRNA-seq and Stereo-seq to analyze the immunological microenvironment of cervical squamous cell carcinoma, identifying immune cell clusters and their associations with tumor progression and patient survival.

Bone marrow mesenchymal stem cells stimulated by tumor necrosis factor-α can promote the repair of fatty liver cell oxidative stress injury and fatty liver ischemia-reperfusion injury

This study shows that TNF-α-stimulated BMSCs reduce oxidative stress and tissue damage in fatty liver IRI in rats.

Screening of cell-virus, cell-cell, gene-gene interactions among kingdoms of life at single cell resolution

The paper screens cell-virus and cell-cell interactions across multiple species to identify potential hosts and co-evolution patterns of viruses including SARS-CoV-2.

Previously unrecognized non-reproducible antibody-antigen interactions and their implications for diagnosis of viral infections including COVID-19

The paper identifies non-reproducible antibody-antigen interactions in clinical sera and develops a model to explain them, improving serological testing for viral infections like COVID-19.

Arabidopsis Topless-related 1 mitigates physiological damage and growth penalties of induced immunity

This study identifies TPR1's role in mitigating immune-related physiological damage in Arabidopsis by analyzing its chromatin binding and effects on gene expression and plant growth.

Permeability profiling of all 13 Arabidopsis PIP aquaporins using a high throughput yeast approach

The paper develops a high-throughput yeast assay to profile permeability of all 13 Arabidopsis PIP aquaporins to various substrates and links results to their biological roles and structural features.

Polycomb repressive complex 2 coordinates with Sin3 histone deacetylase complex to epigenetically reprogram genome-wide expression of effectors and regulate pathogenicity in Magnaporthe oryzae

The paper shows that Polycomb repressive complex 2 and Sin3 histone deacetylase complex work together to epigenetically control effector gene expression in Magnaporthe oryzae, regulating its pathogenicity.

Chronic exercise protects against the progression of renal cyst growth and dysfunction in rats with polycystic kidney disease

This study shows that chronic exercise in PCK rats reduces renal cyst growth and dysfunction by modulating specific signaling pathways.

A chloride efflux transporter OsBIRG1 regulates grain size and salt tolerance in rice

This study identifies BIRG1 as a chloride efflux transporter in rice that regulates grain size and salt tolerance by controlling chloride homeostasis.

Direct activation of endothelial cells by SARS-CoV-2 nucleocapsid protein is blocked by Simvastatin

This study identifies SARS-CoV-2 nucleocapsid protein as a potent activator of human endothelial cells, showing that simvastatin inhibits this activation through TLR2/NF-κB and MAPK pathways.

Embedding of exogenous B cell epitopes on the surface of UreB structure generates a broadly reactive antibody response against Helicobacter pylori

This study develops a multi-epitope chimeric antigen (MECU) that generates a broadly reactive antibody response against H. pylori and reduces stomach colonization in mice.

Identification and Evaluation of a Panel of Strong Constitutive Promoters in Listeria monocytogenes for Improving the Expression of Foreign Antigens

The paper identifies and evaluates strong constitutive promoters in Listeria monocytogenes to enhance foreign antigen expression, finding P18 as the most effective.

The SARS-CoV-2 transcriptome and the dynamics of the S gene furin cleavage site in primary human airway epithelia

This study examines the SARS-CoV-2 transcriptome in human airway epithelia, identifying frequent deletions at the S1/S2 boundary and their dynamics in virions.

Collagen induced inflammations

This paper describes a protocol for inducing collagen-induced arthritis (CIA) in mice using bovine collagen type II and Freund's adjuvants, and reports associated enteritis and arthritis outcomes.

Blocking of EGFR Signaling is a Latent Strategy for the Improvement of Prognosis of HPV Induced Cancer

This study identifies EGFR downregulation as a mechanism by which HPV infection improves prognosis in cervical and head and neck cancers, suggesting EGFR inhibitors could be potential anti-HPV therapies.

Long Period Modeling SARS-CoV-2 Infection of in Vitro Cultured Polarized Human Airway Epithelium

This study shows that SARS-CoV-2 infection of polarized human airway epithelium is long-lasting with recurring replication peaks every 7-10 days and requires a high viral load.