An Innovative Mitochondrial-targeted Gene Therapy for Cancer Treatment
K. Chen, P. Ernst, S. Kim, Y. Si, T. Varadkar, M. Ringel, X. Liu, L. Zhou
This paper introduces mLumiOpto, a mitochondrial-targeted gene therapy that disrupts cancer cell mitochondria using light-activated proteins, showing efficacy in reducing tumor burden in mouse models.
bioRxiv · Mar 24, 2024Cancer Biology