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2 papers
Recent·Most cited
K. Chen, P. Ernst, S. Kim, Y. Si, T. Varadkar, M. Ringel, X. Liu, L. Zhou
This paper introduces mLumiOpto, a mitochondrial-targeted gene therapy that disrupts cancer cell mitochondria using light-activated proteins, showing efficacy in reducing tumor burden in mouse models.
bioRxiv · Mar 24, 2024Cancer Biology
P. Ernst, N. Xu, J. Qu, H. Chen, M. S. Goldberg, J. Zhang, B. O'Rourke, X. Liu, L. Zhou
This paper develops an optogenetic method to control mitochondrial membrane potential and shows its effects on cell fate, finding that light-induced depolarization can induce apoptosis or cytoprotection depending on duration and intensity.
bioRxiv · Nov 13, 2018Biophysics