Author

T. Vasanthakumar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

J. L. Rubinstein· 2 shared A. Celli· 1 shared A. J. de Smith· 1 shared B. Tolani· 1 shared C. R. Liem· 1 shared I. B. Seiple· 1 shared J. S. Weissman· 1 shared K. A. Keon· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersBiochemistry

J. L. Rubinstein

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2 papers

Recent·Most cited

Coordinated conformational changes in the V1 complex during V-ATPase reversible dissociation

T. Vasanthakumar, K. A. Keon, S. A. Bueler, M. C. Jaskolka, J. L. Rubinstein

The paper uses cryoEM to study conformational changes in yeast V1 complex during V-ATPase dissociation, revealing how subunit C enables reassembly with VO.

bioRxiv · Nov 9, 2021Biochemistry

Selective Targeting of Ras Mutant Cancers via a New Small Molecule

B. Tolani, A. Celli, Y. Yao, Y. Z. Tan, R. Fetter, C. R. Liem, A. J. de Smith, T. Vasanthakumar, P. Bisignano, I. B. Seiple, J. L. Rubinstein, M. Jost, J. S. Weissman

This paper identifies 249C as a small molecule that selectively targets Ras-mutant cancers by inhibiting V-ATPase, disrupting lysosomal acidification and key survival pathways in Ras-driven tumors.

bioRxiv · Dec 23, 2020Cancer Biology