Author

P. Bisignano

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Cancer Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:deep learning· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:drug response / drug discovery· 1 Assay:electrophysiology· 1 Approach:experimental assay· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Celli· 1 shared A. George· 1 shared A. J. de Smith· 1 shared A. Pinedo· 1 shared B. Tolani· 1 shared C. R. Liem· 1 shared D. M. Zuckerman· 1 shared D. Raleigh· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperCancer Biology

A. Celli

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

The cilia enriched oxysterol 7β,27-DHC is required for polycystin activation

K. Ha, N. Mundt, P. Bisignano, A. Pinedo, E. Cao, J. Reiter, D. Raleigh, M. Delling

This study identifies 7β,27-DHC as a critical oxysterol required for polycystin complex activation in cilia, revealing a lipid-mediated regulatory mechanism for ADPKD.

bioRxiv · Apr 13, 2022 · PreprintPhysiology

Selective Targeting of Ras Mutant Cancers via a New Small Molecule

B. Tolani, A. Celli, Y. Yao, Y. Z. Tan, R. Fetter, C. R. Liem, A. J. de Smith, T. Vasanthakumar, P. Bisignano, I. B. Seiple, J. L. Rubinstein, M. Jost, J. S. Weissman

This paper identifies 249C as a small molecule that selectively targets Ras-mutant cancers by inhibiting V-ATPase, disrupting lysosomal acidification and key survival pathways in Ras-driven tumors.

bioRxiv · Dec 23, 2020Cancer Biology

A systems-biology approach to molecular machines: Exploration of alternative transporter mechanisms

A. George, P. Bisignano, J. Rosenberg, M. Grabe, D. M. Zuckerman

This paper introduces a computational method to explore alternative mechanisms of molecular machines, finding diverse reaction pathways for cotransport with proofreading capabilities.

bioRxiv · Jan 7, 2020Biophysics