Endoplasmic reticulum stress activates human IRE1α through reversible assembly of inactive dimers into small oligomers
V. Belyy, I. Zuazo-Gaztelu, A. Alamban, A. Ashkenazi, P. Walter
This study reveals that IRE1α activation involves reversible dimer-to-oligomer assembly in response to ER stress, with phosphorylation occurring after oligomerization.
bioRxiv · Sep 29, 2021Biophysics