Author

A. F. Brilot

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:cryo-EM· 3 Research Focus:protein structure prediction· 2 Organism:bacteria (other)· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Assay:proteomics· 1

Frequent Co-Authors

A. M. Smith· 2 shared A. N. Rizo· 2 shared C. M. Azumaya· 2 shared D. A. Agard· 2 shared D. Diwanji· 2 shared F. Li· 2 shared G. E. Merz· 2 shared H. C. Nguyen· 2 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersBiophysics

A. M. Smith

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

The {varphi}PA3 Phage Nucleus is Enclosed by a Self-Assembling, 2D Crystalline Lattice

E. S. Nieweglowska, A. F. Brilot, M. Mendez, M. Baek, J. Li, C. Kokontis, Y. Cheng, D. Baker, J. Bondy-Denomy, D. A. Agard

The paper shows that the Phage Nucleus of {phi}PA3 forms a self-assembling, 2D crystalline lattice with adaptable inter-tetramer contacts and functional channels.

bioRxiv · Apr 6, 2022Biochemistry

CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes.

M. Gupta, C. M. Azumaya, M. Moritz, S. Pourmal, A. Diallo, G. E. Merz, G. M. Jang, M. Bouhaddou, A. Fossati, A. F. Brilot, D. Diwanji, E. Hernandez, N. Herrera, H. T. Kratochvil, V. L. Lam, , K. I Pawar

The paper uses cryo-EM and AlphaFold2 to determine the structure of SARS-CoV-2 Nsp2, revealing its zinc-binding site and potential interactions with host proteins.

bioRxiv · May 10, 2021 · PreprintBiophysics

CM1-driven assembly and activation of Yeast γ-Tubulin Small Complex underlies microtubule nucleation

A. F. Brilot, A. Lyon, A. Zelter, S. Viswanath, A. Maxwell, M. J. MacCoss, E. G. Muller, A. Sali, T. N. Davis, D. A. Agard

This study elucidates the role of the CM1 motif in Spc110p in facilitating γ-Tubulin Small Complex (γTuSC) assembly and γ-Tubulin Ring Complex (γTuRC) formation in yeast.

bioRxiv · Nov 21, 2020Biochemistry

An ultra-potent synthetic nanobody neutralizes SARS-CoV-2 by locking Spike into an inactive conformation

M. Schoof, B. Faust, R. A. Saunders, S. Sangwan, V. V. Rezelj, N. Hoppe, M. Boone, C. Billesboelle, C. Puchades, C. M. Azumaya, H. T. Kratochvil, M. Zimanyi, I. Deshpande, J. Liang, S. Dickinson, , Barile-H

This paper develops a potent synthetic nanobody that neutralizes SARS-CoV-2 by locking its Spike protein in an inactive conformation, enabling aerosol delivery as a prophylactic or therapeutic agent.

bioRxiv · Aug 8, 2020Biochemistry