Protective mucosal immunity against SARS-CoV-2 after heterologous systemic RNA-mucosal adenoviral vector immunization
D. Lapuente, J. Fuchs, J. Willar, A. V. Antao, V. Everlein, N. Uhlig, L. Issmail, A. Schmidt, F. Oltmanns, A. S. Peter, S. Mueller-Schmucker, P. Irrgang, K. Fraedrich, A. Cara, M. Hoffmann, , M. Tenbusch
This study shows that intranasal adenoviral vector boosts after mRNA priming enhance mucosal immunity and protection against SARS-CoV-2 in mice.
bioRxiv · Aug 3, 2021Immunology