LAG3 regulates antibody responses in a murine model of kidney transplantation
M. Nicosia, R. Fan, J. Lee, V. Gorbacheva, J. I. Valenzuela, Y. Yamamoto, A. Beavers, N. Dvorina, E. Chuluyan, M. Araki, W. Baldwin, R. L. Fairchild, B. Min, A. Valujskikh
This study shows that LAG3 deficiency in mice leads to rapid rejection of kidney allografts via antibody-mediated rejection, highlighting LAG3's role in regulating anti-donor humoral immunity.
bioRxiv · Jan 31, 2022 · PreprintImmunology