B. Min

Single cell analysis uncovers striking cellular heterogeneity of lung infiltrating Tregs during eosinophilic vs. neutrophilic allergic airway inflammation

The paper uses single-cell RNA sequencing to analyze lung-infiltrating Tregs in eosinophilic and neutrophilic allergic airway inflammation models, revealing significant heterogeneity and tissue-residency differences.

Intronic miR342 is a master regulator of cellular glycolysis in Foxp3+ regulatory CD4 T cells

This study identifies miR-342 as a master regulator of glycolysis in Foxp3+ regulatory T cells, essential for controlling inflammation in the central nervous system.

Lymphocyte activation gene 3 (Lag3) supports Foxp3+ Treg cell function by restraining c-Myc-dependent aerobic glycolysis

This study shows Lag3 supports Foxp3+ Treg cell function by restraining c-Myc-dependent aerobic glycolysis, which is critical for suppressing autoimmune inflammation.

IFN-induced protein with tetratricopeptide repeats 2 (Ifit2) limits autoimmune inflammation by regulating myeloid cell activation and metabolic activity

This study identifies Ifit2 as a regulator of myeloid cell activation and metabolic activity, which limits autoimmune inflammation in EAE.

LAG3 regulates antibody responses in a murine model of kidney transplantation

This study shows that LAG3 deficiency in mice leads to rapid rejection of kidney allografts via antibody-mediated rejection, highlighting LAG3's role in regulating anti-donor humoral immunity.

Cell type specific IL-27p28 (IL-30) deletion uncovers an unexpected regulatory function of IL-30 in autoimmune inflammation

This study shows that IL-30, a subunit of IL-27, has a regulatory role in autoimmune inflammation, with its expression by APCs limiting inflammation, while dendritic cell-derived IL-30 is not required for disease development.

BATF3-dependent induction of IL-27 by B cells bridges the innate and adaptive stages of the antibody response

B cells integrate innate TLR and adaptive CD40 signals to induce BATF3 transcription factor for production of IL-27, which together with INFg optimizes antibody responses.