BiophysicsbioRxiv
Single-molecule imaging with cell-derived nanovesicles reveals early binding dynamics at a cyclic nucleotide-gated ion channel
V. R. Patel, A. M. Salinas, D. Qi…·M. P. Goldschen-Ohm
The paper uses cell-derived nanovesicles and single-molecule imaging to study ligand binding dynamics at a cyclic nucleotide-gated ion channel, revealing previously undetected conformational changes and non-cooperative binding behavior.
DOI 10.1038/s41467-021-26816-5