Viscoelastic Extracellular Matrix Enhances Epigenetic Remodeling and Cellular Plasticity
Y. Wu, Y. Song, J. Soto, T. Hoffman, X. Lin, A. Zhang, S. Chen, R. N. Massad, X. Han, D. Qi, K.-W. Yeh, Z. Fang, J. Eoh, L. Gu, A. C. Rowat, , S. Li
This study shows viscoelastic substrates enhance epigenetic remodeling and cellular plasticity in fibroblasts, improving reprogramming efficiency into neurons and pluripotent stem cells.
bioRxiv · Apr 14, 2024Cell Biology