Covalent Targeting of Glutamate Cysteine Ligase to Inhibit Glutathione Synthesis
L. Zhang, M. Tang, X. Tao, Q. Shao, V. Thomas, S. Shimizu, M. Kasano, Y. Ishikawa, T. Inukai, D. K. Nomura
This study identifies a covalent inhibitor EN25 that targets GCLM to inhibit glutathione synthesis in ARID1A-deficient cancer cells.
bioRxiv · May 18, 2023Biochemistry