Daniel P. Poole

The paper presents cryo-EM structures of the delta opioid receptor with PAMs, identifies a novel allosteric site, and describes a mechanism for enhanced binding and activation.

This study shows TRPV4 mediates histamine receptor signaling in lymphatic endothelial cells, enhancing Ca2+ signaling and NFATc1 translocation while cytokine release occurs through distinct mechanisms.

This study examines the impact of diabetes on the colonic mucus layer and goblet cells in db/db mice, finding a thinner mucus layer and goblet cell hyperplasia.

This study shows that targeting mGlu5 in endosomes improves analgesia by inhibiting nuclear ERK1/2 signaling and reducing neuronal excitability in pain models.

This study investigates the role of cathepsin S and X in inflammatory bowel diseases using activity-based probes and mouse models, finding that cathepsin S contributes to some symptoms but pharmacologic inhibition may have unintended effects.

The paper introduces GAT, a tool for automated analysis of enteric neurons in gut tissue images, improving accuracy and throughput over manual methods.

This paper identifies TRPV4-expressing cell types in the colon and shows limited involvement of TRPV4 in colonic motility.

The paper introduces CLIJ-assistant, a tool that enables interactive GPU-accelerated image processing and cross-platform code generation for bio-image analysis.