G6PD deficiency mediated impairment of iNOS and lysosomal acidification affecting phagocytotic clearance in microglia in response to SARS-CoV-2
A. Mondal, S. Munan, I. Saxena, S. Mukherjee, P. Upadhyay, N. Gupta, W. Dar, A. Samanta, S. Singh, S. Pati
This study shows that G6PD deficiency in microglia impairs iNOS-mediated NO production and lysosomal acidification, leading to reduced phagocytosis of SARS-CoV-2 and increased COVID-19 severity.
bioRxiv · Dec 12, 2023Cell Biology