Author

W. Enard

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Evolutionary Biology· 2 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 6 Assay:bulk RNA-seq· 5 Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Organism:non-human primate· 3 Approach:statistical model· 3 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:differential expression· 2

Frequent Co-Authors

A. Janjic· 3 shared J. Geuder· 3 shared L. E. Wange· 3 shared M. Ohnuki· 3 shared A. Leunig· 2 shared B. Vieth· 2 shared I. Hellmann· 2 shared K. Pekayvaz· 2 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersImmunology

A. Janjic

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Evidence for compensatory evolution within pleiotropic regulatory elements

Z. Kliesmete, P. Orchard, V. Y. K. Lee, J. Geuder, S. M. Krauss, M. Ohnuki, J. Jocher, B. Vieth, W. Enard, I. Hellmann

The paper investigates how pleiotropy affects the evolution of cis-regulatory elements, finding that more pleiotropic elements show greater conservation in function despite lower sequence conservation.

bioRxiv · Jan 10, 2024Evolutionary Biology

Immunothrombolytic monocyte-neutrophil axes dominate the single-cell landscape of human thrombosis

K. Pekayvaz, M. Joppich, S. Brambs, V. Knottenberg, L. Eivers, A. Martinez-Navarro, R. Kaiser, N. Meissner, B. Kilani, S. Stockhausen, A. J. Janjic, V. Polewka, F. W. Wendler, A. D. zu Senden, A. Leunig, , K. Stark

The paper maps immune cell trajectories and interactions in human thrombi, identifying prothrombotic and thrombolytic monocyte and neutrophil subsets with therapeutic implications.

bioRxiv · Jan 10, 2024 · PreprintImmunology

ARID1A Mutations Protect Follicular Lymphoma from FAS-dependent Immune Surveillance by Reducing RUNX3/ETS1-Driven FAS-Expression

M. Antoniolli, M. Solovey, C. D. Strobl, D. Bararia, W. D. Keay, J. A. Hildebrand, L. Adolph, M. Heide, V. Passerini, T. Freyholdt, L. Wange, W. Enard, S. Thieme, H. Blum, M. Rudelius, , O. Weigert

This study identifies ARID1A mutations in follicular lymphoma that reduce FAS expression, enabling immune evasion by disrupting RUNX3/ETS1 regulation.

bioRxiv · Dec 12, 2023 · PreprintCancer Biology

GPR55 in B cells limits atherosclerosis development and regulates plasma cell maturation

R. Guillamat-Prats, D. Hering, M. Rami, C. Haerdtner, D. Sanovito, P. Rinne, L. Bindila, M. Hristov, S. Pagano, N. Vuilleumier, S. Schmid, A. Janjic, W. Enard, C. Weber, L. Maegdefessel, , S. Steffens

This study shows that GPR55 in B cells reduces atherosclerosis by regulating plasma cell maturation and antibody production.

bioRxiv · Dec 20, 2021Immunology

Regulatory and coding sequences of TRNP1 co-evolve with brain size and cortical folding in mammals

Z. Kliesmete, L. E. Wange, B. Vieth, M. Esgleas, J. Radmer, M. Huelsmann, J. Geuder, D. Richter, M. Ohnuki, M. Goetz, I. Hellmann, W. Enard

The paper examines how TRNP1's regulatory and coding sequences co-evolve with brain size and cortical folding across mammals, finding significant correlations with brain size and increased TRNP1 activity.

bioRxiv · Feb 5, 2021Evolutionary Biology

Protective immune trajectories in early viral containment of non-pneumonic SARS-CoV-2 infection

K. Pekayvaz, A. Leunig, R. Kaiser, S. Brambs, M. Joppich, A. Janjic, O. Popp, V. Polewka, L. E. Wange, C. Gold, M. Kirchner, M. Muenchhoff, J. C. Hellmuth, C. Scherer, T. Eser, , L. Nicolai

This study identifies an early interferon-stimulated gene (ISG) upregulation as a protective immune signature in non-pneumonic SARS-CoV-2 infection, preventing progression to pneumonia.

bioRxiv · Feb 3, 2021Immunology

A non-invasive method to generate induced pluripotent stem cells from primate urine

J. Geuder, M. Ohnuki, L. E. Wange, A. Janjic, J. Bagnoli, S. Müller, A. Kaul, W. Enard

This paper develops a non-invasive method to generate induced pluripotent stem cells (iPSCs) from primate urine, validated in humans and applied to gorilla and orangutan samples.

bioRxiv · Aug 12, 2020Cell Biology