S. Schmid

Cntnap2 deletion in mice causes developmentally transient alterations in auditory processing and persistent startle hyperreactivity

This study shows that Cntnap2 deletion in mice causes transient auditory brainstem changes and persistent startle hyperreactivity in males, similar to rats but with sex-specific effects.

Host-use Drives Convergent Evolution in Clownfish and Disentangles the Mystery of an Iconic Adaptive Radiation

This study identifies sea anemone host use as the driver of convergent evolution in clownfish color and morphology, resolving a long-standing mystery in adaptive radiation.

ERK signaling promotes resistance to TRK kinase inhibition in NTRK fusion-driven glioma mouse models.

This study shows ERK signaling promotes resistance to TRK inhibitors in NTRK fusion-driven glioma mouse models and suggests MEK inhibition as a potential combination therapy.

Ongoing hybridisation among clownfishes: the genomic architecture of the Kimbe Bay hybrid zone

The paper examines the genomic structure of a clownfish hybrid zone, identifying first-generation hybrids and early backcrosses, and suggests adaptive introgression from one parent species.

Gene flow throughout the evolutionary history of a polymorphic and generalist clownfish

This study uses whole-genome data to show A. clarkii has a single species status with pervasive gene flow and color polymorphism not linked to population structure.

Nanopores reveal the stoichiometry of single oligo-adenylates produced by type III CRISPR-Cas

This study uses a nanopore assay with a CNN to detect and determine the stoichiometry of single cOAs produced by type III CRISPR-Cas systems.

Molecular control of endurance training adaptation in mouse skeletal muscle

The paper identifies molecular changes in mouse skeletal muscle due to endurance training and shows how training status affects transcriptional and proteomic responses to acute exercise.

Orientation-locked DNA origami for stable trapping of small proteins in the NEOtrap

This paper improves the NEOtrap by orienting DNA origami to enhance trapping of small proteins, achieving longer observation times and reduced noise.

Extensive hybridisation throughout clownfishes evolutionary history

This study investigates hybridisation in clownfishes, finding multiple past hybridisation events that support its role in adaptive radiation.

Cell-free Tumor Methylome Analysis of Small Cell Lung Cancer Patients Identifies Subgroups with Prognostic Associations

This study uses cfMeDIP-seq to analyze cell-free methylomes in SCLC patients, identifying prognostic methylome clusters associated with biological pathways and repeat elements.

The GEF-GAP pair Solo and DLC3 balances Rho activity during endocytic transport

This study identifies Solo and DLC3 as a RhoGAP-RhoGEF pair that regulates RhoB activity and levels during endocytic transport through combined RNAi screening and biochemical assays.

Can DyeCycling break the photobleaching limit in single-molecule FRET?

This paper introduces DyeCycling, a method to extend single-molecule FRET observation time beyond photobleaching limits, enabling millisecond resolution for over an hour.

GPR55 in B cells limits atherosclerosis development and regulates plasma cell maturation

This study shows that GPR55 in B cells reduces atherosclerosis by regulating plasma cell maturation and antibody production.

Inferring kinetic rate constants from single-molecule FRET trajectories - a blind benchmark of kinetic analysis tools

This study benchmarks eleven tools for inferring kinetic rate constants from smFRET trajectories using simulated and experimental data with varying challenges.

Nanopore electro-osmotic trap for the label-free study of single proteins and their conformations

This paper introduces NEOtrap, a method to trap and observe single proteins for hours with high time resolution, enabling label-free analysis of protein conformations and dynamics.

Same Equilibrium. Different Kinetics. Protein Functional Consequences.

This study uses single-molecule FRET to show that Hsp90's ATPase function is regulated by different kinetic mechanisms, not just thermodynamics, and introduces the concept of functional stimulation through conformational confinement.

Comparing current noise in biological and solid-state nanopores

The paper compares noise characteristics in biological and solid-state nanopores, finding that SiNx solid-state nanopores offer the highest signal-to-noise ratio, with controlled slowdowns significantly enhancing SNR.

Effects of inhibitors on Hsp90’s conformational dynamics, cochaperone and client interactions

This study investigates how Hsp90 inhibitors affect its conformational dynamics and interactions with cochaperones and clients, finding minimal impact on global transitions and binding.