Author

W. Lees

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:human· 2 Assay:long-read sequencing· 2 Research Focus:benchmarking· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1

Frequent Co-Authors

C. T. Watson· 3 shared G. Yaari· 3 shared A. M. Collins· 2 shared A. Peres· 2 shared M. L. Smith· 2 shared A. Obraztsova· 1 shared A. Omer· 1 shared A. Shepherd· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersImmunology

C. T. Watson

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4 papers

Recent·Most cited

Resolving haplotype variation and complex genetic architecture in the human immunoglobulin kappa chain locus in individuals of diverse ancestry

E. Engelbrecht, O. L. Rodriguez, K. Shields, S. Schulze, D. Tieri, U. Jana, G. Yaari, W. Lees, M. L. Smith, C. T. Watson

The paper uses long-read sequencing to resolve haplotype variation and genetic architecture in the human IGK locus across diverse ancestries, identifying novel variants and population-specific allele frequencies.

bioRxiv · Oct 23, 2023Immunology

A BALB/c IGHV Reference Set, defined by haplotype analysis of long-read VDJ-C sequences from F1 (BALB/c / C57BL/6) mice

K. J. Jackson, J. T. Kos, W. Lees, W. S. Gibson, M. L. Smith, A. Peres, G. Yaari, M. Corcoran, C. E. Busse, M. Ohlin, C. T. Watson, A. M. Collins

The paper defines a BALB/c IGHV reference set by analyzing long-read VDJ-C sequences from F1 mice, identifying strain-specific variations and germline alleles not present in existing genome references.

bioRxiv · Feb 28, 2022Immunology

T Cell Receptor Beta Germline Variability is Revealed by Inference From Repertoire Data

A. Omer, A. Peres, O. L. Rodrigues, C. T. Watson, W. Lees, P. Polak, A. M. Collins, G. Yaari

The paper identifies undocumented polymorphisms in T cell receptor Beta genes using AIRR-seq data and shows how a single SNP affects TCR repertoire composition.

bioRxiv · May 17, 2021Immunology

sumrep: a summary statistic framework for immune receptor repertoire comparison and model validation

B. J. Olson, P. Moghimi, C. Schramm, A. Obraztsova, D. Ralph, J. A. Vander Heiden, M. Shugay, A. Shepherd, W. Lees, F. A. Matsen

sumrep is an R package for analyzing and comparing immune receptor repertoires, showing that recombination features are more discriminative than amino acid composition summaries and that generative models capture some but not all repertoire properties.

bioRxiv · Aug 6, 2019Immunology