Author

D. Ralph

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 6

Signature Assays, Organisms & Methods

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Assay:proteomics· 5 Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:human· 4 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Research Focus:benchmarking· 1 Approach:comparative / phylogenetic analysis· 1

Frequent Co-Authors

F. A. Matsen· 5 shared J. Overbaugh· 5 shared A. Dhar· 2 shared D. M. Depierreux· 2 shared D. N. Sather· 2 shared F. Ruiz· 2 shared H. Y. Chu· 2 shared J. A. Williams· 2 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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5 shared papersImmunology

F. A. Matsen

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Author profile →

6 papers

Recent·Most cited

Delineating the functional activity of antibodies with cross-reactivity to SARS-CoV-2, SARS-CoV-1 and related sarbecoviruses

F. Ruiz, W. Foreman, M. Lilly, V. A. Baharani, D. M. Depierreux, V. Chohan, A. L. Taylor, J. Guenthoer, D. Ralph, F. A. Matsen, H. Y. Chu, P. D. Bieniasz, M. Cote, T. N. Starr, J. Overbaugh

This study identifies cross-reactive antibodies against SARS-CoV-2 and related sarbecoviruses that target conserved epitopes and show broad neutralization potential.

bioRxiv · Apr 24, 2024Immunology

The S2 subunit of spike encodes diverse targets for functional antibody responses to SARS-CoV-2

J. Guenthoer, M. E. Garrett, M. Lilly, D. M. Depierreux, F. Ruiz, M. Chi, C. I. Stoddard, V. Chohan, K. Sung, D. Ralph, H. Y. Chu, F. A. Matsen, J. Overbaugh

This paper identifies diverse functional antibodies targeting the S2 subunit of SARS-CoV-2 spike, including one with broad neutralization activity across multiple coronaviruses.

bioRxiv · Feb 26, 2024 · PreprintImmunology

Development of antibody-dependent cell cytotoxicity function in HIV-1 antibodies

L. E. Doepker, S. Danon, E. Harkins, D. Ralph, Z. Yaffe, A. Dhar, C. Wagner, M. Stumpf, D. Arenz, J. A. Williams, W. Jaoko, K. Mandaliya, K. K. Lee, F. A. Matsen, J. Overbaugh

This study reconstructs the developmental pathways of HIV-specific ADCC antibodies and identifies mutations required for antigen binding and ADCC function.

bioRxiv · Sep 24, 2020 · PreprintImmunology

Diversity and function of maternal HIV-1-specific antibodies at the time of vertical transmission

L. Doepker, C. Simonich, D. Ralph, T. A. Gobillot, M. Garrett, V. Vigdorovich, D. N. Sather, R. Nduati, F. Matsen, J. Overbaugh

This study isolates and characterizes HIV-specific neutralizing antibodies from a mother of a vertically infected infant, revealing their diversity and functional properties.

bioRxiv · Sep 23, 2019Immunology

sumrep: a summary statistic framework for immune receptor repertoire comparison and model validation

B. J. Olson, P. Moghimi, C. Schramm, A. Obraztsova, D. Ralph, J. A. Vander Heiden, M. Shugay, A. Shepherd, W. Lees, F. A. Matsen

sumrep is an R package for analyzing and comparing immune receptor repertoires, showing that recombination features are more discriminative than amino acid composition summaries and that generative models capture some but not all repertoire properties.

bioRxiv · Aug 6, 2019Immunology

Rapid development of an infant-derived HIV-1 broadly neutralizing antibody lineage

C. A. Simonich, L. Doepker, D. Ralph, J. A. Williams, A. Dhar, Z. Yaffe, L. Gentles, C. T. Small, B. Oliver, V. Vigdorovich, V. Mangala Prasad, R. Nduati, D. N. Sather, K. K. Lee, F. A. Matsen, J. Overbaugh

This study reconstructs the developmental lineage of an infant-derived HIV-1 broadly neutralizing antibody, showing a rapid evolution with fewer mutations compared to adult antibodies.

bioRxiv · Sep 13, 2018Immunology