A Rap1 binding site and lipid-dependent helix in talin F1 domain promote integrin activation in tandem
A. Gingras, F. Lagarrigue, M. Cuevas, M. Zorovich, A. Valadez, M. A. Lopez-Ramirez, N. Seban, W. McLaughlin, K. Ley, W. Kiosses, M. Ginsberg
The paper identifies a novel Rap1 binding site in talin1 F1 domain and shows its cooperation with a lipid-dependent amphipathic helix to enable integrin activation.
bioRxiv · Apr 13, 2019Cell Biology